Sam and Dean investigate the murder of a lawyer and his wife, who claimed to have seen a ghost before they were killed. However, local authorities arrest the Winchesters after…

Dean calls a demon to make a deal to save a man named Evan Hudson, in exchange for himself. While making the deal, the demon confronts Dean’s worst nightmare about…

Sam has a vision of Dean shooting a defenseless man, and they go to the town of River Grove, where they find the townspeople have been possessed by a virus…

In the aftermath of the car crash, the surviving Winchesters go to the hospital, where one is stalked by a Reaper while another must consider sacrificing himself to save the…

After the events at the hospital, the brothers have no idea where the demon that killed their mother is hiding. While biding their time trying to come up with an…

Sam and Dean encounter a vampire hunter whose obsession may get them all killed.

Dean and Sam investigate the death of a young college student who died in a car accident, but whose grave is now surrounded by a circle of dead plants.

Cristina gets to scrub in on a rare surgery which incites envy. Alex questions his future in plastics. George and Addison work together with Noelle. Noelle is pregnant with twins…

The men of Seattle Grace go on a camping trip together, Addison and Callie must team up to work on a patient, Meredith assists Sloan with a procedure unlike any…

George’s father has a serious heart problem that requires surgery and George chooses Burke to do the procedure. Burke doubts himself because he knows the pressure this kind of surgery…

A traumatic car accident fills the ER. Izzie pushes the boundaries of her probation. Cristina has a crisis of conscience about her deceptive teamwork with Burke.

Recent events strain Burke and Cristina’s relationship. Mark and Derek must work together when two close-knit brothers seek medical help. One of Meredith’s half sisters is admitted to the hospital.

Meredith must make an important choice about which path she wants to follow to determine the future of her love life. While she considers her future she and others have…

Cristina meets Burke’s parents, the interns try to get Izzie’s job back, and Addison takes a day off, a surgical patient may be living her last day. Some of the…

The staff tries to prevent a patient from getting an elective surgery. Cristina tries to help Preston cope with the after effects of his surgery. A patient bails on their…

Shawn Sullivan, a car salesman who just had surgery, wants to get back to his routine so he doesn’t lose his renown. Addison works with a pregnant woman named Rebecca…

Derek learns one of Addison’s secrets. Bailey talks about motherhood and depression to a mother who is set to have cancer surgery and who seems to not care about any…

This episode is the second part of a two-hour season finale. Richard tries to get information from Addison about a family member’s condition. Callie and George have a talk about…

Denny needs a heart or else. Izzie and George go crazy trying to get him one. Derek has the life of a friend in his hands as he operates on…

Derek is still operating when he finds out about Meredith’s current situation. Meredith is freaking out about her situation. Webber and Bailey are dealing with medical health issues. Cristina and…

Derek and Addison’s relationship is rocked to the core when a former friend comes to Seattle Grace and his presence promises to shake things up for a few members of…

Meredith and George are experiencing morning-after tension at home and at work and it has the rest of the doctors wondering what’s up. Derek and Addison are experiencing their own…

The doctors are up to their necks in their usual levels of drama. Meredith is dealing with the backlash of sleeping with George, George and Burke are bonding in ways…

After a series of deaths at the hospital some of the staff become very superstitious. Izzie worries about Denny and gets confronted by Alex. A patient with OCD drives Cristina…

Meredith and Izzie take up knitting. Derek operates on Andrew, a spelling bee champ with a serious head injury. Bailey gets in on Andrew’s surgery because she’s worried that her…

Addison’s patient is a Catholic mother of seven. Addison gets in trouble after learning that the patient’s husband won’t use contraceptives. Derek treats a divorce attorney who asks if Derek…

The staff attends to an intern from another hospital who has short-term memory loss. This intern, named Marshall, also has caused a car accident that involved a married couple, their…

George and Derek work together, Denny still doesn’t have a heart, and Meredith gets paired with Callie. A 12-week pregnant girl dies in the O.R. and her parents try to…

Cristina is bothered by a new year’s mandatory work limit. Izzie patient, Denny Duquette, wants two things: 1. a heart transplant, 2. Izzie. Addison detests Derek’s trailer, Derek visits Meredith’s…

Meredith and Cristina lie to each other and themselves about their relationships with McDreamy and Burke, respectively. George is given a hard task to expel a discharged and defiant woman…

All the nurses at Seattle Grace Hospital go on strike, leaving the doctors to fend for themselves. George refuses to cross the picket line and finally joins the nurses on…

An explosive case arrives at the O.R. that might endanger all the lives of the people working there, which leads Dr. Burke to declare a “Code Black” for the hospital….

Heylia treats Nancy like the trash that she thinks she is. Peter’s captain looks over his notes on the DEA bust. Celia and Doug’s relationship hasn’t changed since last week….

Peter isn’t happy about the nickname “Agent Wonderbread” and he lets Nancy and Conrad know so with a convinving threat. Nancy looks to other people in the business for help….

Nancy is having one of the worst and busiest days of life. One of sons is missing. Shane’s graduation and the deal with U-Turn make her feel like she needs…

Peter makes a visit to Heylia’s house with some of his DEA friends. Nancy and Conrad install a safe in the grow house. Doug tries to ruin Celia’s new job…

Nancy does her best to cope with the loss of Conrad’s help, who runs into some trouble while venturing out on his own. Andy is still trying to get into…

While Nancy is trying to figure out what do with Peter, she comes home to problems of plumbing that are related to Shane and his arrival into puberty. Celia enrolls…

Nancy takes on an alias to help Conrad set up the grow house. Isabelle get approached to be a model. Interesting things happen to Celia while she’s on the campaign…

Isabelle is auditioning for the Huskeroo ads afterall. Once Celia sees that Isabelle has an opportunity to go national she may change her mind about Isabelle’s involvement. Celia is still…