Cristina, Izzie and Meredith take care of Shane, a man who appears to be crazy and claims that he is pregnant. Shane’s case induces a spreading fascination among the staff….

Bill is heartbroken when the beautiful jogger he’s pining for falls for Boomhauer, who is in turn heartbroken himself when the jogger dumps him.

When Max is fascinated by an intriguing autistic child he wonders if his own lost child is attempting to reach out to him. Meanwhile, Michael plays Santa to Maria and…

Liz continues her investigation into Alex’s death while Isabel plans her future and Maria wonders whether Michael will always be around.