Azumi tells James the whole truth about the study’s snags and urges him to call his estranged mother, an esteemed therapist.

Owen and Annie take the C pill. No longer connected, he belongs to a Mafia family, and she’s a medieval guide hired by an ailing elf princess.

Annia and Ellia continue their quest, and Owen’s mafioso father pressures him to protect the family. Greta counsels a bereaved Gertie.

Owen and Annie meet again as a disgraced Icelandic spy and a CIA operative who helps him. Greta implores James to shut down the trial.

After the subjects are discharged, James and Azumi face Neberdine’s CEO. Owen and Annie part ways — until a startling headline sparks a reunion.

When her pilfered stash of pills runs out, troubled Annie tries to quit — but ends up blackmailing her way into the Neberdine study.

Muramoto notices irregularities in Annie and Owen’s data. He questions Owen, who recalls the worst night of his life: his brother’s engagement party.

Annie and Owen are Arlie and Ollie, grifters attending a séance at the mysterious Neberdine mansion in the 1940s.

Diagnosed with schizophrenia, Owen is the black sheep of the wealthy Milgrim clan. After losing his job, he enrolls in an experimental drug trial.

The entire NYPD is mobilized to find the killer of an off-duty police officer murdered during a diamond heist.

Penguin takes a hit for Galavan’s murder, but doesn’t let Gordon off easily. Meanwhile, Gordon and Bullock investigate the body-snatching spree of Victor Fries, one of Gotham’s preeminent cryogenics engineers.

Barrow can alleviate a debt if he treats one of Collier’s wounded men and also urges Capt. Robertson to buy one of Thomas Edison’s new inventions. Meanwhile, Algernon tries a…

Refusing to collaborate with Dr. Zinberg on blood-transfusion research, an increasingly paranoid Thackery pushes himself to the limit, and beyond, in an effort to “solve the riddle” and beat his…

Already fuming over the hospital’s faulty new electrical system, Thackery tasks Herman Barrow, the Knick’s crooked superintendent, to deliver more cadavers so that he and his team can test out…

Thackery weighs performing surgery on a former flame, and orders Gallinger and Chickering to experiment on pigs. Barrow goes the extra yard to square a debt. After a bad day…