Jesse, Tulip and Cassidy hit a bump in the road and decide to leave New Orleans. An old foe resurfaces and causes a change of plans.

Jesse tries to be a “good preacher,” unaware that a mysterious duo is after him. Meanwhile, the enigmatic Cowboy is introduced.

Riley, Maya, Farkle and Lucas start their freshmen year and quickly learn their place as smaller fish in a much bigger lake.

When Gloria’s mother and sister visit, they bring traditions, baby names and family baggage; Phil helps the kids with their problems; Mitchell and Cameron try to correct Lily’s bad habits.