Something unnatural is happening in the swamps outside Marais, Louisiana. When a mysterious illness strikes the town, CDC investigator (and former Marais native) Abby Arcane is sent to investigate.

Grace questions her involvement in the Coralie Hunter case when the D.A. threatens to reopen her case with Mac. The Bishop and Lady Mae disagree on hosting “A Day with…

In a final and drastic attempt to save Nic from Lane’s acts of sabotage, Conrad must call in a favor from the one person he promised he never would. Meanwhile,…

Much to Bell’s dismay, Nic and Conrad decide to admit a homeless Jane Doe, whom they suspect was dumped off by another hospital during Chastain’s big Charity Ball. Elsewhere in…

Conrad receives the call he’s been waiting for when a heart becomes available for a patient who has been on the transplant list for two years. But when a congressman…

As Mac and the team investigate the suspicious death of Dawn’s CIA supervisor, the evidence leads to a dirty CIA agent and a massive counterfeiting ring.

Dr. Manning and Dr. Charles assist in a complicated case helping a 4-year old who they quickly learn is no stranger to the ED. Dr. Marcel and Dr. Choi tend…

Dr. Charles and Goodwin fear Dr. Halstead is repeating his past mistakes when a patient with early-onset Alzheimer’s is brought into the E.D. Maggie and Ben become concerned when one…

Dr. Choi and Dr. Marcel don’t see eye-to-eye over the treatment of a patient’s chronic pain and rumors start to circulate about Maggie. Dr. Manning works to help a young…

Dr. Manning’s actions with a recent patient lead to serious repercussions. April and Noah disagree over a patient who is injured after a beating. Dr. Charles is visited by a…

Maggie gets unsettling news about a new friend and breaks protocol to support him. One of the doctors from the Med family is rushed into emergency surgery after a violent…

April receives unfortunate news that makes her question her future with Ethan. Dr. Charles and Maggie see tough times on the horizon. Natalie’s memory from the accident starts to return.

An auto accident sends Goodwin into a spiral as she tries to help a young boy and his mother. Natalie’s secretive behavior begins to draw the attention of Dr. Marcel…

An infection threatens Marcel’s risky liver transplant. Maggie and Charles help a struggling burn unit nurse. Goodwin is forced to make a tough decision about Bert’s future.

Ripley and Charles treat a high-risk prisoner who may have dementia. Archer and Sean clash when a resident from Margo’s facility lands in the E.D. Marcel receives shocking news.

Ripley and Charles treat members of a cult. Ahmad’s suspension takes an unexpected toll on Marcel. Abrams’ 5-month-old son lands in the E.D. under questionable circumstances.

Maggie empathizes with a patient whose mother is afraid to consent to her son’s risky surgery. Ripley treats someone from his past. Ahmad questions her instincts.

Goodwin is worried after an accident lands two people close to her in the E.D. Archer returns to Med and treats a man concerned about a family curse. Maggie and…

Goodwin recruits Charles to evaluate her ex-husband’s memory. Archer treats one of Sean’s peers from the rehab center. Asher treats a woman from a rural clinic whose miscarriage was improperly…

A hacker demanding a ransom payment shuts down the hospital computer system, forcing the doctors to diagnose patients without the aid of technology. A stressed Goodwin struggles to keep the…

Dr. Rhodes second guesses removing himself from the team working to separate conjoined twins; Dr. Choi and April make a startling discovery about his sister; Dr. Charles uncovers troubling information…

Dr. Charles feels pressure when Dr. Choi and Dr. Manning criticize his medical decision regarding an ill newborn baby. Dr. Rhodes comes to terms with his relationship issues. Goodwin helps…

The brutal murder of a lottery winner has Castle and Beckett up to their eyeballs in suspects, envious and angered by the victim’s sudden move from the poorhouse to the…

The staff prepares for the worst as they make arrangements for the public announcement of the President’s condition; Sam and Babish grill Abbey about her medical treatment of the President’s…

On the day of Mrs. Landingham’s funeral, the staff deals with a Haitian presidential crisis and the law suit against the big tobacco companies, and Bartlet must decide about running…

The President delivers his 3rd State of the Union address, what critics call “the speech of his political career” and ends up angering Abbey by what he does and doesn’t…

Bartlet authorizes a special ops team to rescue the five DEA agents only to have them caught in an ambush; CJ arranges for the host of “Capitol Beat” to have…

On the day before the New Hampshire primary, Josh drafts Donna as his frontwoman to ensure that Bartlet wins the nation’s first primary in the small town of Hartsfield’s Landing;…

Josh investigates the suicide of a pilot with whom he has things in common; Donna tries to get an invitation to the Congressional Christmas party to hear Yo-Yo Ma perform;…

When an American spy submarine suddenly goes silent in hostile North Korea, Bartlet must decide whether to inform the enemy or attempt a secret rescue operation; Abbey learns her past…

Bartlet’s decision about Haiti falls under scrutiny; C.J. makes a horrible blunder in a press conference and is hounded about the president’s health by reporters; the staff disagrees about whether…

As Thanksgiving approaches, Tony’s feud with Ralph escalates, despite the intervention of Johnny Sack. At a frat-house mixer, Meadow and Jackie Jr. find they have more in common than mob-boss…

Tony’s concerns that his mother will rat him out to the feds expire when she, literally, does. Later, Janice arrives to arrange the funeral, which takes a bizarre turn.

When black protesters start picketing a construction company that used to be under Uncle Junior’s control, Tony meets with the owner–as well as the leader of the protestors–to ‘fix’ the…

Will sneaks Philip’s elderly mother out of the house for a night on the town.