A cursed survivor of killings at the Amityville House brings evil to a small island where bizarre genetic experiments are carried out on humans and animals.

A homicide detective sees similarities between herself and the victims of a killer who is murdering clinical phobics by exposing them to their fears.

A young woman and her friends are threatened by an ancient witch’s curse when they stop in the town of Amityville to check in on her sickly grandmother.